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Peptides. 2013 Aug;46:167-71. doi: 10.1016/j.peptides.2013.06.006. Epub 2013 Jun 24.

Decreased plasma nesfatin-1 levels in patients with acute myocardial infarction.

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  • 1Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.


Nesfatin-1 is a novel anorexigenic hormone which has close relationship with diabetes, obese, anorexia nervosa, psychiatric disorders and neurogenic diseases. The aim of our study was to evaluate levels of plasma nesfatin-1 among patients presenting with coronary artery disease and the correlation between nesfatin-1 levels and other clinical parameters. Fasting plasma levels of nesfatin-1 were tested in 48 acute myocardial infarction (AMI) patients, 74 stable angina pectoris (SAP) patients and 34 control subjects. All of them were examined by coronary angiography. The severity of coronary atherosclerosis was assessed using the Gensini score. Plasma nesfatin-1 levels were significantly lower in AMI group than SAP group or control group (0.91±0.08 ng/mL vs. 0.98±0.19 ng/mL and 1.09±0.39 ng/mL, respectively, P<0.05). In AMI patients, plasma nesfatin-1 levels were negatively correlated with high-sensitivity C-reactive protein, neutrophil% or Gensini scores. Such information implies that lower nesfatin-1 concentration may play a very important role in the development of AMI.

Copyright © 2013 Elsevier Inc. All rights reserved.


Acute myocardial infarction; Angina pectoris; Angiography; Nesfatin-1

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