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Clin Res Hepatol Gastroenterol. 2013 Dec;37(6):564-71. doi: 10.1016/j.clinre.2013.05.009. Epub 2013 Jun 24.

Methylation and liver cancer.

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  • 1Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, via Manzoni 56, Rozzano, MI, Italy. Electronic address:


Cancer evolution at all stages (including initiation, progression and invasion) is driven by both epigenetic abnormalities and genetic alterations. Epigenetics refer to any structural modification of genomic regions, which lead to modification in gene expression without alterations in DNA sequence. Progressive deregulation of epigenetic process is being increasingly recognized in liver carcinogenesis. This review will provide an overview of DNA methylation, one of the most commonly epigenetic events, which profoundly contributes to liver cancer initiation and progression. Furthermore, the recent advancements in the knowledge of epigenetic reprogramming underlying hepatic cancer stem cells will be highlighted.

Copyright © 2013 Elsevier Masson SAS. All rights reserved.

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