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Cancer Lett. 2013 Oct 10;339(2):260-9. doi: 10.1016/j.canlet.2013.06.018. Epub 2013 Jun 22.

miR-146b-5p inhibits glioma migration and invasion by targeting MMP16.

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  • 1Dept. of Neuropathology, Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin 300052, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China.

Abstract

miR-146b-5p is frequently down-regulated in solid tumours, including prostate cancer, pancreatic cancer, and glioblastoma. However, the tumour-suppressive effects of miR-146b-5p in malignant gliomas have not been investigated thoroughly. Here, we found that decreased miR-146b-5p expression was strongly correlated with chromosome 10q loss in gliomas, especially glioblastomas. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. Our results suggest that the restoration of miR-146b-5p expression may be a feasible approach for inhibiting the migration and invasion of malignant gliomas.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Gliomas; Invasion; MMP16; Migration; miR-146b-5p

PMID:
23796692
[PubMed - indexed for MEDLINE]
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