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Hum Immunol. 2013 Nov;74(11):1470-3. doi: 10.1016/j.humimm.2013.06.004. Epub 2013 Jun 17.

Clinical relevance of GSTT1 mismatch in solid organ and hematopoietic stem cell transplantation.

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  • 1Immunology Service, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Spain. Electronic address: iaguilera-ibis@us.es.

Abstract

Since 2001, year in which Glutathione S-transferase theta class 1 (GSTT1) gene appeared to be related to the occurrence of de novo immune hepatitis after liver transplantation, this gene with two allelic variants, GSTT1(∗)A (wild type copy) and GSTT1(∗)0 (deletion copy), has emerged as a potent histocompatibility antigen. Namely, a donor-recipient liver graft combination of a GSTT1-negative recipient (homozygous for GSTT1(∗)0) and a GSTT1-positive donor results, very frequently, in the appearance of a severe immune-related graft hepatitis with production of IgG anti-GSTT1 antibodies. In kidney transplantation, GSTT1 donor-recipient mismatch is also associated with production of anti-GSTT1 antibodies and antibody-related rejection episodes with C4d deposition in graft biopsy. The more recent discovery of anti-GSTT1 antibodies in hematopoietic stem cell transplantation, clearly confirms a role of GSTT1 as histocompatibility antigen in this setting. Interestingly, the consequences of GSTT1 mismatch might be either rejection or graft-versus-host disease, depending on the GSTT1 mismatch's sense of direction. The involvement of GSTT1 in immunological allo-recognition is unquestionable although there are still many aspects that remain to be explored.

Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Ab; GSTM1; GSTT1; Glutathione S-transferase mu 1; Glutathione S-transferase theta 1; HSCT; LT; antibody; hematopoietic stem cell transplantation; liver transplant; mHag; minor histocompatibility antigen

PMID:
23792056
[PubMed - indexed for MEDLINE]
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