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Neurosci Lett. 2013 Aug 9;549:63-8. doi: 10.1016/j.neulet.2013.06.002. Epub 2013 Jun 19.

Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat.

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  • 1Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.

Abstract

Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective effect of paeonol on STZ-induced DE rats. Paeonol of 25, 50, 100mg/kg (p.o.) could decrease the latency time and path length, and enhance significantly the spent time in the target quadrant and platform crossings in Morris water maze test. The treatment with paeonol could also increase significantly Na(+)-K(+)-ATP enzyme and ChAT activities, as well as decreasing significantly AchE activity in hippocampal tissue. Immunohistochemistry and TUNEL staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors BDNF and IGF expressions, and also ameliorate Aβ deposition in the hippocampus and cerebral cortex. In conclusion, the present study demonstrated diabetic rats treated with paeonol could ameliorate the cognition deficits. These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of DE.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

AChE; Anti-apoptosis; Aβ; BDNF; ChAT; Cognition deficits; DE; Diabetic encephalopathy; HGF; IGF; Na(+)-K(+)-ATPase; Na(+)-K(+)-adenosine triphosphatase; Neuropathological changes; Paeonol; STZ; acetylcholinesterase; amyloid beta; brain derived neurotrophic factor; choline acetyltransferase; diabetic encephalopathy; high-glucose-fat diet; insulin-like growth factors; streptozotocin; β-amyloid

PMID:
23791853
[PubMed - indexed for MEDLINE]
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