Carving axon arbors to fit: master directs one kinase at a time

Daisuke Satoh; Silvia Arber

doi:10.1016/j.cell.2013.05.047

Carving axon arbors to fit: master directs one kinase at a time

Cell. 2013 Jun 20;153(7):1425-6. doi: 10.1016/j.cell.2013.05.047.

Authors

Daisuke Satoh¹, Silvia Arber

Affiliation

¹ Biozentrum, University of Basel, 4056 Basel, Switzerland.

PMID: 23791171
DOI: 10.1016/j.cell.2013.05.047

Abstract

Pyramidal neurons in the cortex require the master kinase LKB1 for early axon specification. Courchet et al. now uncover a later role for LKB1 and its tango with the downstream effector kinase NUAK1 in controlling terminal axonal branching through influencing mitochondrial motility in axons.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

AMP-Activated Protein Kinases
Animals
Axons / metabolism*
Female
Male
Mitochondria / metabolism*
Neurons / cytology*
Protein Kinases / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Repressor Proteins / metabolism*
Signal Transduction*

Substances

Repressor Proteins
Protein Kinases
NUAK1 protein, mouse
Protein Serine-Threonine Kinases
Stk11 protein, mouse
AMP-Activated Protein Kinases