Effect of pharmacologic pupil dilation on OLCR optical biometry measurements for IOL predictions

Eur J Ophthalmol. 2014 Jan-Feb;24(1):53-7. doi: 10.5301/ejo.5000332. Epub 2013 Jun 17.

Abstract

Purpose: To determine the possible influence of pupil dilation on intraocular lens (IOL) power predictions made using optical biometry with Lenstar LS 900® (Haag-Streit AG, Koeniz, Switzerland).

Methods: A total of 72 eyes of 72 patients scheduled to undergo cataract surgery were prospectively examined using the optical low-coherence reflectometry (OLCR) optical biometer before and after pupil dilation with tropicamide 1%. The measurements made were axial length, central corneal thickness, anterior chamber depth (ACD), lens thickness, mean keratometry, corneal diameter (CD), and pupil diameter. Holladay II and SRK/T formulas were used to calculate IOL power. Agreement between the 2 measurement modes (with and without dilation) was assessed by calculating intraclass correlation coefficients (ICC) and constructing Bland-Altman plots.

Results: The mean age of the patients was 74.71 ± 7.53 years (range 56-90). Among the variables determined, only ACD varied significantly according to pupil dilation (p<0.001). The ICC data revealed excellent intraobserver correlation between measurements made with and without dilation, except for CD. The IOL power predictions were unmodified.

Conclusions: The use of pupil dilation does not seem to influence measurements and IOL predictions made using this OLCR optical biometer.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Axial Length, Eye
  • Biometry*
  • Cataract Extraction*
  • Female
  • Humans
  • Interferometry
  • Lens Implantation, Intraocular*
  • Light
  • Male
  • Middle Aged
  • Mydriatics / administration & dosage*
  • Observer Variation
  • Optics and Photonics*
  • Prospective Studies
  • Pupil / drug effects*
  • Tropicamide / administration & dosage*
  • Visual Acuity

Substances

  • Mydriatics
  • Tropicamide