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J Nucl Med. 2013 Aug;54(8):1320-2. doi: 10.2967/jnumed.112.118885. Epub 2013 Jun 19.

Influence of TSPO genotype on 11C-PBR28 standardized uptake values.

Author information

  • 1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. kkyoder@iupui.edu

Abstract

(11)C-PBR28 binds to the high-affinity state of the translocator protein 18 kDa (TSPO). A single-nucleotide polymorphism (rs6971) within the human TSPO gene determines the affinity state of the TSPO. The rs6971 genotype determines whether individuals express the high-, low-, or mixed-affinity phenotype of TSPO. The rs6971 genotype corresponds to in vivo (11)C-PBR28 binding, as measured quantitatively by total volume of distribution. However, it is not known whether standardized uptake value (SUV) can detect differences in brain (11)C-PBR28 uptake by TSPO genotype.

METHODS:

Thirty-two older adults (71.8 ± 7.94 y old) underwent (11)C-PBR28 PET scanning; rs6971 genotype was imputed after genomewide genotyping. SUV was extracted for several brain regions. The sample included 19 C/C carriers (high-affinity phenotype), 12 T/C carriers (mixed-affinity), and 1 T/T carrier (low-affinity) for rs6971.

RESULTS:

SUV was 30% lower in T/C subjects than in C/C subjects.

CONCLUSION:

The results indicate that brain (11)C-PBR28 SUV is sensitive to TSPO genotype.

KEYWORDS:

11C-PBR28; TSPO; genotype; positron emission tomography

PMID:
23785173
[PubMed - indexed for MEDLINE]
PMCID:
PMC3740346
[Available on 2014/8/1]
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