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Front Integr Neurosci. 2013 Jun 11;7:43. doi: 10.3389/fnint.2013.00043. eCollection 2013.

Motor abnormalities as a putative endophenotype for Autism Spectrum Disorders.

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  • 1RIKEN Brain Science Institute, Unit for Affiliative Social Behavior Wako-Shi, Saitama, Japan.

Abstract

Autism Spectrum Disorders (ASDs) represent a complex group of behaviorally defined conditions with core deficits in social communication and the presence of repetitive and restrictive behaviors. To date, neuropathological studies have failed to identify pathognomonic cellular features for ASDs and there remains a fundamental disconnection between the complex clinical aspects of ASDs and the underlying neurobiology. Although not listed among the core diagnostic domains of impairment in ASDs, motor abnormalities have been consistently reported across the spectrum. In this perspective article, we summarize the evidence that supports the use of motor abnormalities as a putative endophenotype for ASDs. We argue that because these motor abnormalities do not directly depend on social or linguistic development, they may serve as an early disease indicator. Furthermore, we propose that stratifying patients based on motor development could be useful not only as an outcome predictor and in identifying more specific treatments for different ASDs categories, but also in exposing neurobiological mechanisms.

KEYWORDS:

Autism Spectrum Disorders; early assessment; early screening; endophenotype; motor abnormalities

PMID:
23781177
[PubMed]
PMCID:
PMC3678087
Free PMC Article
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