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J Int Med Res. 2013 Apr;41(2):340-6. doi: 10.1177/0300060513476430.

Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population.

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  • 1Department of Geriatrics, The West China Hospital of Sichuan University, Sichuan Province, China.

Abstract

OBJECTIVE:

To examine the association between the circadian locomotor output cycles kaput (CLOCK) gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease in Chinese people.

METHODS:

This case-control study determined apolipoprotein E (APOE) and CLOCK rs1554483 G/C genotypes using polymerase chain reaction restriction fragment length polymorphism.

RESULTS:

Unrelated patients with Alzheimer's disease (n = 130) and healthy controls (n = 188) were analysed for an association between the CLOCK gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease. In the whole sample and in APOE ε4 isoform noncarriers, the prevalence of CLOCK gene rs1554483 G allele carriers was significantly higher in patients with Alzheimer's disease than in controls. Among APOE ε4 carriers, the prevalence of CLOCK rs1554483 G allele carriers was not significantly different between patients with Alzheimer's disease and controls.

CONCLUSION:

Among APOE ε4 noncarriers, but not APOE ε4 carriers, the CLOCK rs1554483 G allele was associated with increased susceptibility to Alzheimer's disease.

KEYWORDS:

APOE ε4 isoform; Alzheimer's disease; CLOCK gene rs1554483 G/C; apolipoprotein E (APOE); circadian locomotor output cycles kaput (CLOCK); polymorphism

PMID:
23781009
[PubMed - indexed for MEDLINE]
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