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Hong Kong Med J. 2013 Jun;19 Suppl 4:36-8.

Development of anti-influenza A compounds: a pilot study.

Author information

  • 1Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China. bzheng@hkucc.hku.hk

Abstract

1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound— BFDBSC—can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds—FPBFDBSC and BFB-gallate— showed higher antiviral effectsthan BFDBSC, whearas the other two—BFB-borneol and BFB-menthol—showed lower antiviral effects. These compounds did not show toxicity. 5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility

PMID:
23775185
[PubMed - indexed for MEDLINE]
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