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Exp Mol Pathol. 2013 Oct;95(2):121-3. doi: 10.1016/j.yexmp.2013.06.003. Epub 2013 Jun 14.

Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells.

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  • 1New York University School of Medicine, Cancer Institute, Smilow Research Building 1303, 522 First Avenue, New York, NY 10016, USA.

Abstract

OBJECTIVE:

The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus.

METHODS:

Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI ≥ 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation.

RESULTS:

The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality.

CONCLUSION:

cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Autoimmunity; Dendritic cells; Disease activity; Systemic lupus erythematosus

PMID:
23773850
[PubMed - indexed for MEDLINE]
PMCID:
PMC3963522
Free PMC Article
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