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Pediatr Transplant. 2013 Sep;17(6):E146-8. doi: 10.1111/petr.12114. Epub 2013 Jun 17.

Successful allogeneic hemopoietic stem cell transplantation in a case of Wiskott-Aldrich syndrome and non-Hodgkin lymphoma.

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  • 1Department of Pediatric Hematology, Ankara Children's Hematology and Oncology Hospital, Diskapi, Ankara, Turkey. betultavil@yahoo.com

Abstract

WAS is a severe X-linked recessive disorder characterized by microthrombocytopenia, eczema, and immunodeficiency. A six-yr-old boy with WAS diagnosed as B-cell NHL (Stage III) localized in the liver who underwent successful HSCT from HLA-one antigen mismatch sibling donor has been presented here. His conditioning regimen included ATG, busulfan, and fludarabine. He received 2.3 × 10(6) /kg CD 34+ stem cells and 11 × 10(8) /kg nucleated cells at day 0. Neutrophil engraftment was achieved at day +14 and platelet engraftment at day +20. He has been in CR for more than two yr after transplantation. Thus, HSCT is an effective treatment for children with WAS even after development of lymphoma.

© 2013 John Wiley & Sons A/S.

KEYWORDS:

Wiskott-Aldrich syndrome; allogenic stem cell transplantation; non-Hodgkin lymphoma; pediatrics

PMID:
23773507
[PubMed - indexed for MEDLINE]
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