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Pediatr Int. 2013 Dec;55(6):727-30. doi: 10.1111/ped.12157. Epub 2013 Aug 21.

Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants.

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  • 1Department of Neonatology, Perinatal Medical Center, Kagoshima City Hospital, Kagoshima, Japan.



We conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low-birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000 g.


With a combination of enteral administration of miconazole (6 mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5 mg/kg/day and 3 mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth.


The prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group.


MCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low-birthweight infants.

© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.


extremely low-birthweight infants; fluconazole; fungal infections; micafungin; miconazole; prophylaxis

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