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ACS Macro Lett. 2013 Apr 24;2(5):393-397.

Generating Better Medicines for Cancer.

Author information

  • 1Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

The complexity of tumor biology warrants tailored drug delivery for overcoming the major challenges faced by cancer therapies. The versatility of the PRINT® (Particle Replication In Non-wetting Templates) process has enabled the preparation of shape- and size-specific particles with a wide range of chemical compositions and therapeutic cargos. Different particle matrices and drugs may be combined in a plug-and-play approach, such that physico-chemical characteristics of delivery vectors may be optimized for biocompatibility, cargo stability and release, circulation half-life, and efficacy. Thus, the engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process.

KEYWORDS:

PRINT; cancer; drug delivery; medicine; nanoparticle; soft lithography

PMID:
23772351
[PubMed]
PMCID:
PMC3680140
Free PMC Article
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