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J Cancer Res Ther. 2013 Apr-Jun;9(2):284-6. doi: 10.4103/0973-1482.113387.

Low-grade myofibroblastic sarcoma of the larynx: a rare entity with review of literature.

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  • 1Department of Radiotherapy and Oncology, Regional Cancer Centre, Chandigarh, India.


Mesenchymal neoplasms of the larynx are rare and make up approximately 0.3% to 1.0% of all malignancies at this location. Low grade myofibroblastic sarcoma (LGMS) of larynx is a rare entity. We describe a rare case of LGMS of larynx who presented with complaint of hoarseness of voice. The patient was treated with total laryngectomy plus partial pharyngectomy followed by post-operative radiotherapy. Histopathologically, the lesion was composed of spindle cells that manifested variable cellular anaplasia and expressed smooth muscle actin (SMA) and focally S-100.One of the resection limits was involved so patient was given post-operative radiotherapy. The patient is alive and disease free 14 months after surgery. The characteristic clinical, histopathological features and treatment of this case are described with a literature review.

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