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J Cancer Res Ther. 2013 Apr-Jun;9(2):250-2. doi: 10.4103/0973-1482.113377.

The expression of Heparanase mRNA and its clinical significance in Hepatocellular carcinoma.

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  • 1Department of General Surgery, Jiangsu Shengze Hospital, Wujiang, Jiangsu, China.

Abstract

OBJECTIVE:

To investigate the clinico-pathologic importance of Heparanase mRNA expression in hepatocellular carcinoma and its relationship with prognosis.

MATERIALS AND METHODS:

Fresh tumors and noncancerous liver tissues were obtained from 30 hepatocellular carcinoma patients after hepatectomy. Expression levels of Heparanase and glyceraldehyde-3-phosphate dehydrogenase mRNA were quantitatively analyzed by real-time reverse transcriptase-polymerase chain reaction.

RESULTS:

The relative Heparanase mRNA expression level (Heparanase: glyceraldehyde-3-phosphate dehydrogenase ratio) in hepatocellular carcinoma was lower than that in noncancerous tissue (P < 0.05).

CONCLUSION:

Reduced Heparanase mRNA expression might result in abnormal cell growth and correlate with hepatocellular carcinoma progression.

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