Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Rep. 2013 Jun 27;3(6):1815-23. doi: 10.1016/j.celrep.2013.05.014. Epub 2013 Jun 13.

Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity.

Author information

  • 1Development and Neuropharmacology Group, College de France, Centre for Interdisciplinary Research in Biology, CNRS UMR 7241, Labex Memolife, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, France.

Abstract

Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant circuits and in the primary visual cortex reopens binocular plasticity to restore vision in amblyopic mice. The potential to regulate adult cortical plasticity through the choroid plexus underscores the importance of this structure in brain physiology and offers therapeutic approaches to recovery from a broad range of neurodevelopmental disorders.

Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk