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Clin Neurophysiol. 2013 Nov;124(11):2172-80. doi: 10.1016/j.clinph.2013.05.007. Epub 2013 Jun 14.

Correlation of risk-taking propensity with cross-frequency phase-amplitude coupling in the resting EEG.

Author information

  • 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea; Neuropsychiatry Research Laboratory, Department of Psychiatry, Gongju National Hospital, Chungcheongnam-do 314-200, South Korea; Addiction Brain Center, Eulji Addiction Institute, Gangnam Eulji Hospital, Seoul 135-010, South Korea.

Abstract

OBJECTIVE:

Recent evidence has suggested that the weak inhibitory influence of the prefrontal cortex on the subcortical structures may be responsible for risk-taking behaviour. The aim was to determine the possibility that this weakness in top-down control is reflected in changes in the cross-frequency phase-amplitude coupling (CFPAC) in the electroencephalography (EEG).

METHODS:

Nineteen-channel EEGs were recorded from 50 healthy volunteers with their eyes closed before risk-taking propensity was assessed by behavioural measures, the domain-specific risk-taking (DOSPERT) scale and the Barrett impulsiveness scale (BIS). Correlation analyses between the CFPACs and the behavioural measures were performed.

RESULTS:

The CFPACs were negatively correlated with the risk-taking DOSPERT and BIS scores in frontal (Fp2) and centro-parietal (C3, C4 and P4) regions. By contrast, the CFPACs were positively correlated with the risk-taking DOSPERT and BIS scores in the right hemisphere (T8 and P8).

CONCLUSIONS:

We suggest that frequent risk-taking behaviour is closely associated with the reduced interference of the cortical control network on the reward-oriented system. The CFPAC, which reflects the degree of interactions among functional systems, provides information about an individual's risk-taking propensity.

SIGNIFICANCE:

The CFPAC may be a useful neurophysiological indicator of an individual's tendency towards risk-taking behaviours, which thus potentially contributes to evaluating the severity of the psychiatric diseases exhibiting abnormal risk-taking behaviours.

Published by Elsevier Ireland Ltd.

KEYWORDS:

Barrett impulsiveness scale (BIS); Cross-frequency phase–amplitude coupling (CFPAC); Domain-specific risk-taking (DOSPERT) scale; Risk-taking propensity (RTP)

PMID:
23770089
[PubMed - indexed for MEDLINE]
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