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Curr Opin Struct Biol. 2013 Oct;23(5):669-77. doi: 10.1016/j.sbi.2013.05.005. Epub 2013 Jun 13.

Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules.

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  • 1Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne NE2 4HH, United Kingdom. Electronic address: harry.gilbert@newcastle.ac.uk.

Abstract

Plant cell walls are complex configurations of polysaccharides that are recalcitrant to degradation. The enzymes deployed by microbes to degrade these materials comprise glycoside hydrolases, polysaccharide lyases, carbohydrate esterases and polysaccharide oxidases. Non-catalytic carbohydrate-binding modules (CBMs) are found as discretely folded units within the multi-modular structures of these enzymes where they play critical roles in the recognition of plant cell wall components and potentiating the activity of the enzymes. Here we propose a refinement to the Types A, B, and C classification of CBMs whereby the Type A CBMs remain those that bind the surfaces of crystalline polysaccharides but the Type B CBMs are redefined as those that bind internally on glycan chains (endo-type), CBMs that bind to the termini of glycan chains are defined as Type C modules (exo-type). In this context, we discuss recent advances, primarily driven by structural studies, which reveal the molecular modes of CBM-sugar interactions and how this specifically underpins and influences the biological function of CBMs in cell wall recognition and degradation.

Copyright © 2013 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
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