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Yale J Biol Med. 2013 Jun 13;86(2):235-44. Print 2013 Jun.

Late-life onset bipolar disorder presenting as a case of pseudo-dementia: a case discussion and review of literature.

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  • 1Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.


Depression and comorbid cognitive impairment in the elderly can be difficult to distinguish from dementia. Adding to the complex differential is that depression may be part of a bipolar illness rather than a unipolar mood disorder. A diligent workup and close monitoring of patients can inform appropriate treatment and can make the difference between recovery and persistence of symptoms. The present case will illustrate how a comprehensive workup utilizing extensive data gathering, laboratory workup, use of neuropsychological testing, neuroimaging, and timely treatment can lead to successful clinical outcomes that can be sustained for many years.


late life onset bipolar disorder; pseudo-dementia

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