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Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7690-3. doi: 10.1002/anie.201303690. Epub 2013 Jun 13.

The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.

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  • 1Université Lille1, Unité de Catalyse et Chimie du Solide-UMR CNRS 8181, B.P. 90108, 59652 Villeneuve d'Ascq Cedex, France.

Abstract

Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

bioorganometallic chemistry; ferroquine; malaria; reactive species; subcellular imaging

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