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Cancer Cell. 2013 Jun 10;23(6):711-3. doi: 10.1016/j.ccr.2013.05.016.

Cancer Stem Cells Activate STAT3 the EZ Way.

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  • 1Brain Tumor Research Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Activated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associated with the most malignant subset of gliomas. In this issue of Cancer Cell, Kim and colleagues discover that EZH2 enhances STAT3 activation by trimethylating lysine180 in STAT3 and does so preferentially in glioma stem-like cells.

Copyright © 2013 Elsevier Inc. All rights reserved.

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PMID:
23763996
[PubMed - indexed for MEDLINE]
PMCID:
PMC3706087
Free PMC Article
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