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Biomed Res Int. 2013;2013:454085. doi: 10.1155/2013/454085. Epub 2013 May 26.

Increased expression of TRPS1 affects tumor progression and correlates with patients' prognosis of colon cancer.

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  • 1Department of General Surgery, Shanghai Putuo District Center Hospital, Shanghai 200062, China.

Abstract

AIM:

To detect the expression pattern of tricho-rhino-phalangeal syndrome-1 (TRPS1) in human colon cancer and to analyze its correlation with prognosis of patients with this disease.

METHODS:

The expressions of TRPS1 in human colon cancer and its corresponding noncancerous colon tissues were detected at both mRNA and protein levels.

RESULTS:

The mRNA and protein expression levels of TRPS1 were both significantly higher in colon cancer than in corresponding noncancerous colon tissues (both P < 0.001). The protein level of TRPS1 in colon cancer tissues was significantly correlated with the mRNA level (r = 0.9, P < 0.001). Additionally, immunohistochemistry analysis also found increased TRPS1 expression in 63.0% (63/100) of colon cancer tissues. High TRPS1 expression was significantly associated with positive lymph node metastasis (P = 0.006) and higher pathological stage (P = 0.008) of patients with colon cancer. Multivariate Cox regression analysis further suggested that the increased expression of TRPS1 was an independent poor prognostic factor for this disease.

CONCLUSION:

Our data offer the convincing evidence for the first time that the increased expression of TRPS1 may be involved in the pathogenesis and progression of colon cancer. TRPS1 might be a potential marker to predict the prognosis in colon cancer.

PMID:
23762846
[PubMed - indexed for MEDLINE]
PMCID:
PMC3677607
Free PMC Article
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