Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurobiol Aging. 2013 Nov;34(11):2445-8. doi: 10.1016/j.neurobiolaging.2013.05.002. Epub 2013 Jun 4.

Exceptional memory performance in the Long Life Family Study.

Author information

  • 1Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Department of Neurology, New York, NY 10032, USA. smb2174@columbia.edu

Abstract

Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ≥ 1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (β = 0.74, standard error = 0.19, p = 1.4 × 10(-4)). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Exceptional memory; Genetic variants; Long Life Family Study; Quantitative trait

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk