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Cancer Invest. 2013 Jul;31(6):365-73. doi: 10.3109/07357907.2013.800095. Epub 2013 Jun 11.

A walnut-enriched diet reduces the growth of LNCaP human prostate cancer xenografts in nude mice.

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  • 1Department of Cellular and Structural Biology, University of Texas Health Science Center , San Antonio, Texas, USA. reiter@uthscsa.edu

Abstract

It was investigated whether a standard mouse diet (AIN-76A) supplemented with walnuts reduced the establishment and growth of LNCaP human prostate cancer cells in nude (nu/nu) mice. The walnut-enriched diet reduced the number of tumors and the growth of the LNCaP xenografts; 3 of 16 (18.7%) of the walnut-fed mice developed tumors; conversely, 14 of 32 mice (44.0%) of the control diet-fed animals developed tumors. Similarly, the xenografts in the walnut-fed animals grew more slowly than those in the control diet mice. The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet.

PMID:
23758186
[PubMed - indexed for MEDLINE]
PMCID:
PMC3709881
Free PMC Article
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