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J Expo Sci Environ Epidemiol. 2014 Mar-Apr;24(2):215-21. doi: 10.1038/jes.2013.34. Epub 2013 Jun 12.

Relation between dietary acrylamide exposure and biomarkers of internal dose in Canadian teenagers.

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  • 11] Institut national de santé publique du Québec, Québec, Canada [2] Université Laval, Québec, Canada.
  • 2Institut national de santé publique du Québec, Québec, Canada.
  • 3RTI International, Research Triangle Park, North Carolina, USA.
  • 4Santé Canada, Longueuil, Québec, Canada.
  • 5Département de santé environnementale et santé au travail, Chaire d'analyse et de gestion des risques toxicologiques, Institut de recherche en santé publique, Université de Montréal, Montréal, Québec, Canada.

Abstract

Acrylamide (AA) is a probable human carcinogen found in several foods. Little information is available regarding exposure of adolescents, a subgroup potentially consuming more AA-rich foods. We investigated the relationship between dietary AA intake and levels of biomarkers of exposure (urinary metabolites and hemoglobin adducts) in 195 non-smoking teenagers of Montreal Island aged 10-17 years. Dietary habits and personal characteristics were documented by questionnaire. AA and its metabolites were quantified in 12-h urine collections by LC-MS/MS. Hemoglobin adducts from 165 blood samples were also analyzed by LC-MS/MS. Most prevalent urinary metabolites were NACP and NACP-S, with respective geometric mean concentrations of 31.2 and 14.2 μmol/mol creatinine. Geometric mean concentrations of AAVal and GAVal (hemoglobin adducts of AA and glycidamide (GA) with N-terminal valine residues) were 45.4 and 45.6 pmol/g globin, respectively. AA intake during the 2 days before urine collection was a significant predictor of NACP+NACP-S urinary concentrations (P<0.0001). AA intakes during the month before blood collection (P<0.0001) and passive smoking (P<0.05) were associated with adduct levels. Levels of hemoglobin adducts were above biomonitoring equivalent values corresponding to a 1 × 10(-4) excess cancer risk, which may indicate the need to reduce AA exposure in the population.

[PubMed - indexed for MEDLINE]
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