Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae

ACS Chem Biol. 2013 Sep 20;8(9):1882-7. doi: 10.1021/cb4002552. Epub 2013 Jun 18.

Abstract

The human protein siderocalin (Scn) inhibits bacterial iron acquisition by binding catechol siderophores. Several pathogenic bacteria respond by making stealth siderophores that are not recognized by Scn. Fluvibactin and vibriobactin, respectively of Vibrio fluvialis and Vibrio cholerae , include an oxazoline adjacent to a catechol. This chelating unit binds iron either in a catecholate or a phenolate-oxazoline coordination mode. The latter has been suggested to make vibriobactin a stealth siderophore without directly identifying the coordination mode in relation to Scn binding. We use Scn binding assays with the two siderophores and two oxazoline-substituted analogs and the crystal structure of Fe-fluvibactin:Scn to show that the oxazoline does not prevent Scn binding; hence, vibriobactin is not a stealth siderophore. We show that the phenolate-oxazoline coordination mode is present at physiological pH and is not bound by Scn. However, Scn binding shifts the coordination to the catecholate mode and thereby inactivates this siderophore.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Catechols / chemistry
  • Catechols / metabolism*
  • Humans
  • Iron / metabolism*
  • Lipocalin-2
  • Models, Molecular
  • Oxazoles / chemistry
  • Oxazoles / metabolism*
  • Siderophores / chemistry
  • Siderophores / metabolism*
  • Vibrio cholerae / chemistry
  • Vibrio cholerae / metabolism*

Substances

  • Carrier Proteins
  • Catechols
  • LCN2 protein, human
  • Lipocalin-2
  • Oxazoles
  • Siderophores
  • vibriobactin
  • Iron