Format

Send to:

Choose Destination
See comment in PubMed Commons below
F1000Prime Rep. 2013 Jun 3;5:19. doi: 10.12703/P5-19. Print 2013.

Measurement of disease severity in cutaneous autoimmune diseases.

Author information

  • 1Philadelphia VA Medical Center Philadelphia, PA ; Department of Dermatology, University of Pennsylvania School of Medicine Philadelphia, PA.

Abstract

The development of disease-specific outcome instruments for several autoimmune skin diseases including cutaneous lupus erythematosus (CLE), dermatomyositis, vitiligo, pemphigus and alopecia areata has facilitated the objective assessment of disease in clinical trials. Validation of these instruments provides reliable tools to measure disease severity and therapeutic effect in clinical studies. However, the existence of multiple outcome measures for each disease and the lack of uniformity between studies has created a challenge in comparing results across trials. Efforts to address this issue include the Core Outcome Measures in Effectiveness Trials (COMET) initiative and international meetings directed at reaching a consensus. Other challenges with the use of outcome measures include difficulties measuring change in mild disease, measuring response in topical studies, and capturing disease activity in skin with extensive post-inflammatory hyperpigmentation.

PMID:
23755366
[PubMed]
PMCID:
PMC3673224
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Faculty of 1000 Icon for PubMed Central
    Loading ...
    Write to the Help Desk