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PLoS One. 2013 Jun 3;8(6):e65182. doi: 10.1371/journal.pone.0065182. Print 2013.

Persistent inflammation and endothelial activation in HIV-1 infected patients after 12 years of antiretroviral therapy.

Author information

  • 1Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark. frederikkefr@gmail.com

Abstract

OBJECTIVE:

The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART).

METHODS:

Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin.

RESULTS:

HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls.

CONCLUSION:

Discrete signs of systemic and vascular inflammation persist even after very long term cART.

PMID:
23755191
[PubMed - in process]
PMCID:
PMC3670840
Free PMC Article

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