Send to:

Choose Destination
See comment in PubMed Commons below
Front Immunol. 2013 May 31;4:129. doi: 10.3389/fimmu.2013.00129. eCollection 2013.

Regulation of adaptive immunity; the role of interleukin-10.

Author information

  • 1School of Cellular and Molecular Medicine, University of Bristol , Bristol , UK.


Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and adaptive immune systems. IL-10 is produced by a wide range of cell types, but for the purposes of this review we shall focus on IL-10 secreted by CD4(+) T cells. Here we describe the importance of IL-10 as a mediator of suppression used by both FoxP3(+) and FoxP3(-) T regulatory cells. Moreover, we discuss the molecular events leading to the induction of IL-10 secretion in T helper cell subsets, where it acts as a pivotal negative feedback mechanism. Finally we discuss how a greater understanding of this principle has allowed for the design of more efficient, antigen-specific immunotherapy strategies to exploit this natural phenomenon clinically.


T helper cells; allergy; autoimmunity; cytokines; immune regulation; immunotherapy; interleukin-10; regulatory T cells

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Write to the Help Desk