Send to:

Choose Destination
See comment in PubMed Commons below
J Biol Chem. 2013 Jul 19;288(29):21148-60. doi: 10.1074/jbc.M113.465856. Epub 2013 Jun 10.

The MOV10 helicase inhibits LINE-1 mobility.

Author information

  • 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.


LINE-1 (long interspersed element 1) is an autonomous non-long terminal repeat retrotransposon. Its replication often causes mutation and rearrangement of host genomic DNA. Accordingly, host cells have evolved mechanisms to control LINE-1 mobility. Here, we report that a helicase named MOV10 effectively suppresses LINE-1 transposition. Mutating the helicase motifs impairs this function of MOV10, suggesting that MOV10 requires its helicase activity to suppress LINE-1 replication. Further studies show that MOV10 post-transcriptionally diminishes the level of LINE-1 RNA. The association of MOV10 with both LINE-1 RNA and ORF1 suggests that MOV10 interacts with LINE-1 RNP and consequently causes its RNA degradation. These data demonstrate collectively that MOV10 contributes to the cellular control of LINE-1 replication.


Host-Pathogen Interactions; LINE-1; MOV10; Post-transcriptional; RNA Helicase; Restriction; Retrotransposon; Reverse Transcription; Viral Replication; Virology

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk