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Mar Drugs. 2013 Jun 10;11(6):2042-53. doi: 10.3390/md11062042.

Four new briarane diterpenoids from Taiwanese gorgonian Junceella fragilis.

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  • 1School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Abstract

Four new 8-hydroxybriarane diterpenoids, frajunolides P-S (1-4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).

PMID:
23752357
[PubMed - indexed for MEDLINE]
PMCID:
PMC3721220
Free PMC Article
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