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J Child Neurol. 2014 Nov;29(11):1441-7. doi: 10.1177/0883073813490831. Epub 2013 Jun 10.

Dysembryoplastic neuroepithelial tumor: a clinical, neuroradiological, and pathological study of 15 cases.

Author information

  • 1Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China.
  • 2Department of Neurosurgery, Henan University Huaihe Hospital, Kaifeng, Henan, People's Republic of China.
  • 3Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China zhaoruijiao@126.com.
  • 4Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China.

Abstract

Dysembryoplastic neuroepithelial tumors are rare, surgically curable, neuronal-glial neoplasms affecting young patients with intractable epilepsy. Its recognition is needed to avoid unnecessary adjuvant therapy. The authors reviewed the records of 15 patients with dysembryoplastic neuroepithelial tumors who underwent epilepsy surgery using intraoperative electrocorticography monitoring, including 8 males and 7 females (mean age, 15.8 years). Neuroimaging showed a predominantly intracortical location, the presence of septations, a triangular pattern of distribution, a lack of contrast enhancement, and an absence of peritumoral edema. Eleven cases were classified as complex type, 3 as simple type, and 1 as "nonspecific" type. Associated cortical dysplasia was found in 5 cases and leptomeningeal involvement in 1 case. Its immunophenotype suggested a pluripotential neuroepithelial origin. The mean follow-up was 37.5 months; 2 patients had tumor recurrence. Although they are generally benign neoplasms, recurrences sometimes occur. Complete resection of the tumor with the epileptogenic zone is important for a favorable outcome.

© The Author(s) 2013.

KEYWORDS:

dysembryoplastic neuroepithelial tumor; immunohistochemistry; recurrence; seizure

PMID:
23752069
[PubMed - in process]
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