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Clin Transl Sci. 2013 Jun;6(3):184-90. doi: 10.1111/cts.12043. Epub 2013 Apr 19.

Clinical significance of vimentin expression and Her-2 status in patients with gastric carcinoma.

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  • 1Department of Oncology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China.

Abstract

OBJECTIVES:

To determine whether vimentin could be used as a marker of gastric carcinomas with more aggressive behavior. To detect the extent of Her-2 status in gastric carcinoma and explore the correlation between vimentin expression and Her-2 status.

METHODS:

Vimentin expression was detected in surgically resected gastric carcinoma tissue specimens from 143 patients by immunohistochemistry. The human epidermal growth factor receptor 2 (Her2) status was evaluated by fluorescence in situ hybridization (FISH). Correlations between vimentin expression, Her-2 status and clinicopathological factors were evaluated using Kaplan-Meier method and Cox multivariate survival models.

RESULTS:

Vimentin expression was significantly correlated with age, advanced stage, poorly differentiated type, venous invasion, hepatic metastasis, and recurrence (p < 0.05). Her-2 gene was amplified in 16 (11.2%) out of the 143 gastric carcinoma tissue specimens. Her-2 status was correlated with advanced cancer, poor differentiation, venous invasion, hepatic metastasis, and recurrence (p < 0.05). The result of multivariate analysis showed that vimentin expression and lymph node metastasis were independent prognostic factors.

CONCLUSIONS:

Vimentin expression in epithelial cells of the surgically resected gastric adenocarcinoma tissue is an independent predictor of short survival, and Her-2 status shows a valuable correlation with clinical parameters.

© 2013 Wiley Periodicals, Inc.

PMID:
23751022
[PubMed - indexed for MEDLINE]
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