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Acta Paediatr. 2013 Sep;102(9):908-13. doi: 10.1111/apa.12313. Epub 2013 Jun 26.

Maternal body mass index and the association between folic acid supplements and neural tube defects.

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  • 1Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China.

Abstract

AIM:

To study the influence of maternal body mass index (BMI) on the association between folic acid supplementation and neural tube defects (NTDs) risk in offspring.

METHODS:

A hospital-based, case-control study was conducted between 2006 and 2008 on 459 mothers with NTDs-affected births and 459 mothers without NTDs-affected births. Logistic regression models examined the associations between folic acid supplementation and the NTDs risk in offspring for all mothers, underweight/normal weight mothers (BMI<24.0) and overweight/obese mothers (BMI ≥24.0). The effects were evaluated by adjusted odds ratio (AOR) and 95% confidence intervals (CIs) with SAS 9.1.3 software.

RESULTS:

The overall AOR for periconceptional folic acid supplementation was 0.315 (95% CI = 0.172-0.577) when compared with no supplements. Stratified by maternal BMI, the AOR for periconceptional folic acid supplementation in overweight/obese mothers was greater than in underweight/normal weight mothers (0.646 vs. 0.208). The AOR for folic acid supplementation within 3 months before conception was 0.711 (95% CI = 0.323-1.563) in all mothers. Stratified by maternal BMI, the AOR for folic acid supplementation within 3 months before conception in overweight/obese mothers was greater than in underweight/normal weight mothers (0.658 vs. 0.527).

CONCLUSION:

The association between folic acid supplementation and the reduced NTDs risk was weaker in overweight/obese mothers (BMI ≥24.0) than in underweight/normal weight mothers (BMI <24.0).

©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

KEYWORDS:

Body mass index; Folic acid; Neural tube defects

PMID:
23750819
[PubMed - indexed for MEDLINE]
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