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Nat Genet. 2013 Jul;45(7):776-83. doi: 10.1038/ng.2657. Epub 2013 Jun 9.

The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.

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  • 1State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.

Abstract

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.

PMID:
23749191
[PubMed - indexed for MEDLINE]
PMCID:
PMC4003391
Free PMC Article
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