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Cell Metab. 2013 Jun 4;17(6):883-94. doi: 10.1016/j.cmet.2013.05.004.

Pathways in microbe-induced obesity.

Author information

  • 1Department of Microbiology, New York University Sackler Institute of Graduate Biomedical Sciences, New York, NY 10016, USA.

Abstract

Diet, host gene composition, and alterations in the intestinal microbiota can contribute to obesity. In microbe-induced obesity, metabolic changes stem from primary perturbation of the microbiota, consequent to modern changes in human biology. Microbiota disruption during early development can result in syndromes of metabolic dysfunction. We focus on the pathways involved in these interactions, particularly related to energy extraction and the role of inflammation in the metabolic phenotypes. Model physiologic systems and perturbations including gastric bypass surgery, pregnancy, and hibernation provide insight into the respective roles of the critical participants.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23747247
[PubMed - indexed for MEDLINE]
PMCID:
PMC3727904
Free PMC Article
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