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Psychiatry Res. 2013 Oct 30;209(3):732-3. doi: 10.1016/j.psychres.2013.05.017. Epub 2013 Jun 5.

No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.

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  • 1Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia; High Impact Research Office, Level 9, Chancellery Building, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia. Electronic address:


We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.


Ethnic analysis; Haplotype; rs2494732

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