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Psychiatry Res. 2013 Oct 30;209(3):732-3. doi: 10.1016/j.psychres.2013.05.017. Epub 2013 Jun 5.

No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.

Author information

  • 1Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia; High Impact Research Office, Level 9, Chancellery Building, University of Malaya (UM), 50603 Kuala Lumpur, Malaysia. Electronic address: hcloh@utar.edu.my.

Abstract

We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Ethnic analysis; Haplotype; rs2494732

PMID:
23747160
[PubMed - indexed for MEDLINE]
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