Send to

Choose Destination
See comment in PubMed Commons below
J Hypertens. 2013 Aug;31(8):1517-26. doi: 10.1097/HJH.0b013e328361e4bd.

Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention.

Author information

  • 1Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden.


The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as well as other features of biological ageing. This brief review aims to give an update on EVA and how the concept can be used in clinical practice.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk