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EMBO Rep. 2013 Aug;14(8):741-7. doi: 10.1038/embor.2013.80. Epub 2013 Jun 7.

CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.

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  • 1Institute of Biotechnology, University of Helsinki, Helsinki 00790, Finland.

Abstract

Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (intestinal cell kinase) inhibit ciliogenesis. Depletion of CCRK leads to accumulation of ICK at ciliary tips, altered ciliary transport and inhibition of cell cycle re-entry in NIH3T3 fibroblasts. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. These results indicate that inhibition of ciliogenesis might be a mechanism used by cancer cells to provide a growth advantage.

PMID:
23743448
[PubMed - indexed for MEDLINE]
PMCID:
PMC3736126
Free PMC Article
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