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Muscles Ligaments Tendons J. 2012 Oct 16;2(3):212-21. Print 2012 Jul.

The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair?

Author information

  • 1Center of Translational Regenerative Medicine, Fresenius Medical Care Deutschland GmbH, Torino, Italy.

Abstract

Tendon injuries represent even today a challenge as repair may be exceedingly slow and incomplete. Regenerative medicine and stem cell technology have shown to be of great promise. Here, we will review the current knowledge on the mechanisms of the regenerative potential of mesenchymal stem cells (MSCs) obtained from different sources (bone marrow, fat, cord blood, placenta). More specifically, we will devote attention to the current use of MSCs that have been used experimentally and in limited numbers of clinical cases for the surgical treatment of subchondral-bone cysts, bone-fracture repair and cartilage repair. Based on the recently emerging role in regenerative mechanisms of soluble factors and of extracellular vesicles, we will discuss the potential of non-cellular therapies in horse tendon injuries.

KEYWORDS:

horse tendinopathies; microvesicles; regenerative medicine; soluble factors; stem cells

PMID:
23738299
[PubMed]
PMCID:
PMC3666529
Free PMC Article

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