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Ann Intern Med. 2013 Jun 4;158(11):781-90. doi: 10.7326/0003-4819-158-11-201306040-00002.

Sunscreen and prevention of skin aging: a randomized trial.

Author information

  • 1Queensland Institute of Medical Research and University of Queensland, School of Population Health, Queensland, Australia.

Abstract

BACKGROUND:

Sunscreen use and dietary antioxidants are advocated as preventives of skin aging, but supporting evidence is lacking.

OBJECTIVE:

To determine whether regular use of sunscreen compared with discretionary use or β-carotene supplements compared with placebo retard skin aging, measured by degree of photoaging.

DESIGN:

Randomized, controlled, community-based intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000086066).

SETTING:

Nambour, Australia (latitude 26° S).

PATIENTS:

903 adults younger than 55 years out of 1621 adults randomly selected from a community register.

INTERVENTION:

Random assignment into 4 groups: daily use of broad-spectrum sunscreen and 30 mg of β-carotene, daily use of sunscreen and placebo, discretionary use of sunscreen and 30 mg of β-carotene, and discretionary use of sunscreen and placebo.

MEASUREMENTS:

Change in microtopography between 1992 and 1996 in the sunscreen and β-carotene groups compared with controls, graded by assessors blinded to treatment allocation.

RESULTS:

The daily sunscreen group showed no detectable increase in skin aging after 4.5 years. Skin aging from baseline to the end of the trial was 24% less in the daily sunscreen group than in the discretionary sunscreen group (relative odds, 0.76 [95% CI, 0.59 to 0.98]). β-Carotene supplementation had no overall effect on skin aging, although contrasting associations were seen in subgroups with different severity of aging at baseline.

LIMITATION:

Some outcome data were missing, and power to detect moderate treatment effects was modest.

CONCLUSION:

Regular sunscreen use retards skin aging in healthy, middle-aged men and women. No overall effect of β-carotene on skin aging was identified, and further study is required to definitively exclude potential benefit or potential harm.

PRIMARY FUNDING SOURCE:

National Health and Medical Research Council of Australia.

PMID:
23732711
[PubMed - indexed for MEDLINE]
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