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J Gastrointest Oncol. 2013 Jun;4(2):164-72. doi: 10.3978/j.issn.2078-6891.2013.005.

Recent advances and significance of intra-arterial infusion chemotherapy in non-resectable colorectal liver metastasis.

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  • 1Division of Surgical Oncology and Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.


In era of systemic chemotherapy for colorectal liver metastasis (CLM), role of hepatic intraarterial infusion chemotherapy (HAIC) remains important. We examined treatment effects of HAIC in 36 patients with non-resectable CLM using 5-FU or CPT-11. Tumor response was complete response (CR) in 4, partial response (PR) in 19, stable disease (SD) in 6, and progressive disease (PD) in 7. Tumor control rate was 81% and response rate was 64%. Six patients showed catheter-related complications. Median survival period was 62 months in CR, and 25 with PR. HAIC has a major impact in high chemotherapy response and prolonging survival.


Non-resectable colorectal liver metastasis; hepatic intraarterial infusion chemotherapy; longer survival

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