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Indian J Hematol Blood Transfus. 2012 Jun;28(2):105-8. doi: 10.1007/s12288-011-0116-9. Epub 2011 Dec 11.

A study of plasma fibrinogen level in type-2 diabetes mellitus and its relation to glycemic control.

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  • BLDEA Medical College, Bijapur, Karnataka 431005 India ; MGM Medical College, Aurangabad, Maharashtra India ; C/O Dr. Sachin V. Bembde Plot No. 31, Seven Hills, Jalna Road, Aurangabad, Maharashtra India.

Abstract

The high prevalence of classic cardiac risk factors in patients with type 2 diabetes mellitus does not explain the increased cardiovascular related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. This study is undertaken to know the fibrinogen levels in type 2 diabetes mellitus and its relations to glycemic control. In the present study fibrinogen levels (Clauss method) were estimated in 100 type 2 diabetic subjects and 100 age and sex matched controls. Fibrinogen was correlated with various parameters like glycosylated hemoglobin (cation exchange resin method), age, sex, smoking, body mass index (kg/m(2)), hypertension and ischemic heart disease. Higher plasma fibrinogen levels were found in type 2 diabetes mellitus patients (656 ± 130 mg/dl) as compared to controls (324 ± 139 mg/dl) which were statistically significant. Fibrinogen levels were associated with age (P < 0.01), hypertension (P < 0.01), body mass index (P < 0.01), smoking (P < 0.01), ischemic heart disease (P < 0.01), and glycosylated hemoglobin (r = 0.49) in diabetics in a significant manner. But no correlation was found with sex (P < 0.05) in diabetes. In controls, association was found between fibrinogen levels and smoking (P < 0.01) and body mass index (P < 0.01). Patients with type 2 diabetes mellitus had a high prevalence of hyperfibrinogenemia. Fibrinogen levels were independently associated with hemoglobin A1c values, which suggests that fibrinogen may be involved in the increased cardiovascular risk of patients with type 2 diabetes mellitus.

KEYWORDS:

Blood Transfusion Medicine; Fibrinogen; Glycosylated hemoglobin; Hematology; Human Genetics; Medicine & Public Health; Oncology; Type 2 diabetes mellitus

PMID:
23730017
[PubMed]
PMCID:
PMC3332265
Free PMC Article

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