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    Cleft Palate J. 1990 Jul;27(3):258-64; discussion 264-5.

    Congenital heart anomalies in patients with clefts of the lip and/or palate.

    Source

    Department of Paediatric Cardiology, Institute of Child Health, London, United Kingdom.

    Abstract

    The nature and severity of congenital heart disease in 78 patients who presented with clefts of the lip and/or palate is reported. The prevalence of bilateral cleft lip and palate in patients with heart lesions was much higher than in cleft patients with normal hearts. Cardiac defects were predominantly conotruncal. Tetralogy of Fallot was present in 24 percent of patients; the prevalence of transposition, atrioventricular septal defect, and truncus arteriosus was also disproportionately high. Patients with conotruncal defects had a greater prevalence of either unilateral or bilateral cleft lip and palate. Most patients with congenital heart disease and clefting had additional abnormalities. Anomalies of other systems were found to be present in 87 percent of patients.

    PMID:
    2372974
    [PubMed - indexed for MEDLINE]

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