Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2013 Sep 1;252:18-23. doi: 10.1016/j.bbr.2013.05.039. Epub 2013 May 29.

Specific frequency band of amplitude low-frequency fluctuation predicts Parkinson's disease.

Author information

  • 1Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.

Abstract

Resting-state functional magnetic resonance imaging (RS-fMRI) has been considered for development as a biomarker and analytical tool for evaluation of Parkinson's disease (PD). Here we utilized analysis of the amplitude low-frequency fluctuations (ALFF) to determine changes in intrinsic neural oscillations in 72 patients with PD. Two different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed. In the slow-5 band, PD patients compared with controls had increased ALFF values mainly in the caudate and several temporal regions, as well as decreased ALFF values in the cerebellum and the parieto-temporo-occipital cortex. Additionally, in the slow-4 band, PD patients relative to controls exhibited reduced ALFF value in the thalamus, cerebellum, and several occipital regions. Together, our data demonstrate that PD patients have widespread abnormal intrinsic neural oscillations in the corticostriatal network in line with the pathophysiology of PD, and further suggest that the abnormalities are dependent on specific frequency bands. Thus, frequency domain analyses of resting state BOLD signals may provide a useful means to study the pathophysiology of PD and the physiology of the brain's dopaminergic pathways.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Amplitude low-frequency fluctuation; Corticostriatal network; Parkinson's disease; Resting-state functional magnetic resonance imaging

PMID:
23727173
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk