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Exp Neurol. 2013 Oct;248:10-5. doi: 10.1016/j.expneurol.2013.05.015. Epub 2013 May 28.

Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice.

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  • 1Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan; Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan.

Abstract

Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate herein that AC6 existed in tyrosine hydroxylase-positive rostral ventrolateral medulla neurons in the brainstem. Adenylyl cyclase (AC) assays showed lower basal and pituitary adenylate cyclase-activating peptide-evoked AC activities in the brainstem of AC6-null mice, indicating that AC6 is a prominent AC isozyme in the brainstem. Furthermore, two independent lines of AC6-null mice exhibited a much higher SND, recorded from splanchnic sympathetic nerves of neonatal brainstem-spinal cord preparations, than wildtype mice. An assay of urine noradrenaline confirmed this observation. Collectively, AC6 plays a critical role in the regulation of sympathetic tone.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

AC6; Adenylyl cyclase; Brainstem; Catecholamine; Sympathetic tone; cAMP

PMID:
23726959
[PubMed - indexed for MEDLINE]
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