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Exp Toxicol Pathol. 2013 Nov;65(7-8):1109-15. doi: 10.1016/j.etp.2013.05.001. Epub 2013 May 30.

Gender differences in the incidence of background and chemically induced primary pulmonary neoplasms in B6C3F1 mice: a retrospective analysis of the National Toxicology Program (NTP) carcinogenicity bioassays.

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  • 1Toxicology and Environmental Research and Consulting, Dow Europe GmbH, Horgen, Switzerland. Electronic address:


The National Toxicology Program (NTP) database of technical reports on carcinogenicity bioassays has been interrogated for the incidence of primary pulmonary neoplasms in B6C3F1 mice. A total of 170 study reports were selected, from studies that completed the in-life phase during 1983-2007, which included neoplasm incidence data for 180 control groups comprising both male and female mice. The incidence (median and inter-quartile range) of males with alveolar/bronchiolar adenoma was 16% (12-20%), and for females it was 5% (2-8%); the incidence of males with alveolar/bronchiolar carcinoma was 8% (4-12%), and for females it was 2% (0-4%); and the incidence of males with combined alveolar/bronchiolar adenoma or carcinoma was 24% (18-30%), and for females it was 8% (6-12%). Comparing the incidence of animals bearing these lesions on a per study basis showed the median incidence in males to be 3.0-fold, 2.0-fold, and 2.8-fold higher than in females. The incidence of other primary pulmonary neoplasms was <10% of the alveolar/bronchiolar neoplasms. Comparison of gender-specific response to lung tumorigens showed that the increase in incidence of tumors above control levels was greater in females than in males.

Copyright © 2013 Elsevier GmbH. All rights reserved.


A/B; Adenoma; Alveolar/bronchiolar; B6C3F(1) mouse; BTQ(MF); Carcinoma; GLP; Gender susceptibility; Good Laboratory Practice; Lung; NIH; NIH-07; NIH-31; NTP; NTP-2000; National Institutes of Health; National Toxicology Program; alveolar/bronchiolar; male-to-female background tumor quotient; rodent maintenance diets

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