Format

Send to

Choose Destination
See comment in PubMed Commons below
Res Vet Sci. 2013 Oct;95(2):580-7. doi: 10.1016/j.rvsc.2013.04.021. Epub 2013 May 31.

Population pharmacokinetic analysis of blood concentrations of robenacoxib in dogs with osteoarthritis.

Author information

  • 1Novartis Pharma AG, Modeling & Simulation, CH-4002 Basel, Switzerland. martin.fink@novartis.com

Abstract

The purpose of this analysis was to investigate whether the recommended daily dosage of 1-2mg/kg robenacoxib provides consistent exposure when administered to dogs with chronic osteoarthritis (OA), and the need for dose adjustment in special patient populations. Data from three prospective, multi-center field studies in 208 OA dogs were analyzed using non-linear mixed effects modeling. A model based assessment was performed with stepwise inclusion and exclusion of population characteristics to explain between-subject variability, and assess the according necessity for dose adjustment. Only the influence of bodyweight on both apparent clearance and volume were found to be significant (p<0.01). No significant influence of sex, age and breed, or kidney and liver variables was identified in this representative sample of OA dogs. The population pharmacokinetic analysis performed showed that the 1-2mg/kg dosage chosen provided consistent robenacoxib exposure in a wide range of canine patients. No other dose adjustment seems necessary.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

AUC; BLQ; COX; COXIB; Dog; EBEs; FOCE; IIV; IOV; LLOQ; NSAID; OA; OFV; Population pharmacokinetics; RSE; Robenacoxib; area under the curve; below limit of quantification; cyclooxygenase; empiricial Bayes estimates; first order conditional estimation method; inter-individual variability; inter-occasion variability; lower limit of quantification; non-steroidal anti-inflammatory drug; objective function value; osteoarthritis; relative standard error

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk